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Viagra (Sildenafil citrate), which millions of men take for erectile dysfunction (ED), reduces the effects of hormonal stress on the heart by half, according to a study published online in the journal Circulation. Viagra causes genital blood vessels to expand, which helps in maintaining an erection. Recent research also has pointed to its potential usefulness in treating pulmonary hypertension. Prior to the latest findings by a team of Johns Hopkins researchers, it was thought to have little effect on the heart. Viagra, or sildenafil, blunts the strengthened heart beat caused by chemically induced stress, according to study senior author and cardiologist David Kass, MD, a professor at the Johns Hopkins University School of Medicine and its Heart Institute. It thereby lessens both the excess amount of blood and the force used to pump it to the body. "Sildenafil effectively puts a 'brake' on chemical stimulation of the heart," says Kass. Prevents and Reverses Effects of High BP These findings are believed to be the first confirmation in humans that Viagra has a direct effect on the heart. In earlier research, Kass and his team observed a similar effect in mice; Sildenafil blocked the short-term effects of hormonal stress in the heart. Related studies by the group show that sildenafil also prevents and reverses the long-term effects of chronic high blood pressure on the heart. Sildenafil reversed the negative effects on heart muscle weakened by heart failure and enlargement -- a condition called hypertrophy -- in mouse experiments Kass and his team carried out earlier this year. They reported their results in the journal Nature Medicine. "But we had no firm evidence as to whether or how this therapy might work in the human heart," says Kass. "Our latest research provides firm evidence this drug does indeed have an important impact on the heart." Increased Heartbeat Was Slowed Thirty-five healthy men and women, with an average age of 30 and no previous signs of coronary artery disease, participated in the six-month Johns Hopkins study. Within a three-hour timeframe, each participant received two separate injections of dobutamine (5 micrograms per kilogram for five minutes), a synthetic, adrenaline-like chemical that increases heart rate and pumping strength. Between injections, study participants were assigned randomly to a group that was treated with sildenafil (100 milligrams taken orally) or to a group given a sugar pill placebo. All participants then were given the second dobutamine injection to see what effects sildenafil or placebo had on the heart. Measurements of heart function were made before and after each injection. These included blood pressure readings, electrocardiograms and echocardiograms. Blood samples confirmed relatively equal levels of sildenafil and other enzymes. Each dobutamine injection stimulated heart function, increasing heart rate and the force of each heartbeat used to pump blood throughout the body, results showed. "This stimulation is similar to the way the nervous system normally increases heart function when triggered by emotional or exercise stress, or in diseases such as heart failure," notes Kass. After the first injection of dobutamine, the force of heart contraction increased by 150 percent in both groups. In the placebo group, this increase repeated itself after the second injection. However, in the group treated with sildenafil, the increased heartbeat was slowed by 50 percent, resulting in a smaller increase in blood flow and blood pressure generated by the heart in response to chemical stimulation. Between injections, heart function was not altered in the sildenafil group, demonstrating the absence of adverse side effects on the resting human heart. Stops PDE5A Action "Knowing more about the effects of sildenafil on heart function will allow for safer evaluation of its use as a treatment for heart problems," says Kass. "Our results set the stage for further studies of sildenafil's immediate and long-term effects on the heart and its ability to modify other neurohormonal and stress stimuli, including adrenaline and hypertension," he adds. While the precise biological actions of sildenafil in the heart are not fully understood, the drug is known to work by stopping the action of an enzyme, called phosphodiesterase 5 (PDE5A), Kass explains. This enzyme is involved in the breakdown of a key molecule, cyclic GMP, which helps control stresses and limit overgrowth in the heart. PDE5A is also the biological pathway that sildenafil blocks in the penis to prevent the relaxation of blood vessels and thus maintain erections. Copyright 2005 Daily News Central safe penis elargement penis elargement tip penis elargement surgery cost pnis enlargement surgeries sex vigrx penis enlagement pro solution pills review best penis enlargement pill

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Among a number of problems related with the sexual health of men and of course his partner, we find Premature Ejaculation as the most common sexual problem , this is a pathology characterized by a lack of voluntary control over ejaculation. Masters and Johnson stated that a man suffers from premature ejaculation if he ejaculates before his partner achieves orgasm in more than fifty percent of his sexual encounters. Other sex researchers have defined premature ejaculation as occurring if the man ejaculates within two minutes of penetration; however, a survey by Alfred Kinsey, (yes the inquisitive scientist of the movie the recently showed in theaters) made in the 1950s demonstrated that three quarters of men ejaculated within two minutes of penetration in over half of their sexual encounters. Today, most sex therapists understand premature ejaculation as occurring when a lack of ejaculatory control interferes with sexual or emotional well-being in one or both partners. An estimated thirty percent of men suffer from premature ejaculation on a consistent basis. Premature Ejaculation is believed to be a psychological problem and does not represent any known organic disease involving the male reproductive tract or any known lesions in the brain or nervous system. In short, PE is not a physiological problem or disease, though it manifests physiologically by considering the organ systems directly affected by PE, that include the male reproductive tract (ie, penis, prostate, seminal vesicles, testicles, and their appendages), the portions of the central and peripheral nervous system controlling the male reproductive tract, and the reproductive organ systems of the sexual partner (for the purpose of this discussion, the partner is assumed to be female) that may not be stimulated sufficiently to achieve orgasm. If the PE occurs so early that it happens before commencement of sexual intercourse and the couple is attempting pregnancy, then pregnancy is impossible to achieve unless artificial insemination is used. Perhaps the most affected organ system is the psyche of the partners. Both partners are likely to be dissatisfied emotionally and physically by this problem. Frequency: In the US: The prevalence rate of PE in American males is estimated to range from 30-70%. Internationally: Estimates for European countries and India mirror the prevalence in the United States. The prevalence in other parts of Asia, Africa, Australia, and elsewhere is unknown. Mortality/Morbidity: No known direct morbidity or mortality results from PE. Race: No reproducible data exist on major differences between racial groups with respect to the incidence or prevalence of PE. Sex: PE is a condition that only affects males. Age: PE can occur at virtually any age in an adult man's life. It is most common in younger men (aged 18-30 y), but it also may occur in conjunction with secondary impotence in men aged 45-65 years. If you or someone near you suffers from Premature Ejaculation problems you should know that this is a curable condition. You can learn more at this site: http://www.askingplanet.com male penis enlargment herbal penis enlargement enhancement manhattan penis surgeon pnis enlargement pic penis enhancement herb natural penis enargement pills natural pnis enlargement and lengthening homemade penis enlargement free exercise tip for penis elargement

Rosacea is a chronic, lifelong skin condition that affects (most often) the face. The disease is common: approximately 1 in every 20 Americans has rosacea. Women are affected more often in the early stages (flushing and erythrosis), but more men progress to the advanced stages and rhinophyma is seen almost exclusively in men over 40 years of age. Rosacea is characterized by various skin disorders and sufferers must contend with skin flushing, erythrosis (reddish or purplish discoloration of the skin), teleangiectasia (permanent enlargement of small blood vessels), papulopustular rosacea (papules are small, red, raised bumps; pustules are similar but they contain pus) or rhinophyma (enlarged, red, swollen nose) and for many people, some of these signs and symptoms are very common; approximately 94% of people with rosacea have flushing. These attacks last from a few minutes to several hours, and the flushing seen in rosacea is intermittent in nature. The disease, to a greater or lesser degree, is progressive, and the more pronounced skin lesions will usually follow sporadic episodes of flushing. The exact cause of rosacea has not been determined, but here are many theories. Exposure to the sun may be one factor, and exposure to the sun can precipitate acute episodes of flushing. Another possible cause are skin mites, Demodex folliculorum and Demodex brevis. These tiny insects usually live at the base of hair follicles. They are often found on the faces of people with rosacea, and it has been suggested that they may initiate an inflammatory reaction (Inflammation dilates blood vessels and this contributes to the flush, and it may also damage the blood vessels, causing them to be permanently dilated). Infection with the common bacteria, Helicobacter pylori, has also been suggested as a cause. There may also be genetic defects in the vasculature of the skin that causes hem to become easily - and permanently - dilated. The signs and symptoms of rosacea are not dangerous, but they can be uncomfortable, unsightly, and disfiguring. (However, rosacea can affect the eyes. Approximately 3% to 58% of patients with skin changes will have eye problems and rosacea keratitis can lead to blindness). Yet although there is no cure for rosacea, the disease can be managed. Topical medication, oral medications and laser therapy can all be used to control flushing and to remove some of the skin blemishes, swollen blood vessels and discoloration. However, it would be far more preferable to prevent outbreaks of flushing and the development of erythrosis and papulopustular lesions. It is well known that there are certain factors - sunlight, stress, heat - that can trigger rosacea signs and symptoms, and food has been identified as a trigger. What foods have been implicated as causes of rosacea signs and symptoms? The list is long, and there is obviously individual variations in susceptibility: high doses of B6 and B12, chocolate, tomatoes, hot beverages, hot sausage, red pepper, black pepper, vinegar, paprika, white pepper, garlic, wine, hard liquor, beer, cheese, yogurt, sour cream, milk, citrus fruits, eggplants, avocadoes, spinach, raisins, figs, bananas, and marinated meat. Why do these foods exacerbate rosacea? No one knows for sure, and given the fact that the exact cause of rosacea hasn't been clearly determined, that's not surprising. However a look at the pathophysiology of rosacea may provide some clues. The flush that is so common in people with roseacea is caused by dilation of the small blood vessels of the face. Why this occurs is not certain. The blood vessels may be genetically weak, or they may be damaged by years of exposure to the sun. There may also be an increase in the number of blood vessels, or there may be damage to the walls of the blood vessels. Whatever the cause, the blood vessels (which in the face are very close to the surface) dilate. Many of the foods that trigger flushing attacks most likely do so by increasing body temperature, and in order to lose body heat, blood vessels dilate. Others may cause flushing by stimulating the release of histamine. This is a naturally occurring substance that dilates blood vessels and some foods, e.g. beer and citrus fruits may stimulate the release of histamine. do penis enhancement pills really work penile enlargement tip com enhancement penis penis pump best enlarement exercise penis herbal penile enlargement free exercise tip for penis elargement free exercise tip for penis enlargment natural penis enargement and lengthening free exercise tip for penis elargement

Impotence may have a physical, lifestyle, or psychological cause. An underlying medical condition is the most common cause of impotence. Such conditions may interfere with the blood supply to the penis, the generation of nerve impulses involved in getting and maintaining an erection. Some medical conditions that commonly cause impotence include diabetes, cardiovascular disease, atherosclerosis, or the hardening of the arteries, kidney disease, and diseases affecting the nervous system. Diabetes causes damage to both blood vessels and nerves. Cardiovascular and other vascular diseases reduce the flow of blood to the penis, and the veins that remove blood from the engorged penis may be leaky. Kidney disease may cause impotence through chemical changes that affect circulating hormones, blood supply, nerves and overall energy. Conditions that affect the brain or nerves, such as stroke, Alzheimer’s disease, or multiple sclerosis may all interfere with the flow of nerve impulses that are needed for an erection. Besides medical conditions, surgery that involves the bladder or prostate and pelvic and spinal cord injuries may affect nerves supplying the penis or involved in maintaining an erection. Certain hormonal imbalances such as low testosterone levels can also cause impotence and several types of prescription drugs can cause impotence as a side effect. Lifestyle factors implicated in impotence are lack of physical exercise, being overweight, and the use of alcohol, smoking and illegal drugs. Alcohol and tobacco cause damage to blood vessels and nerves. Lifestyle factors may exist alone or be accompanied by psychological factors such as depression. Psychological causes of impotence include stress, anxiety, depression, or guilt. Sometimes, people who have been physically or sexually abused may suffer from psychological impotence. Another cause of psychological impotence is confusion about one’s sexual identity. Often, someone with an underlying physical condition may also be depressed or anxious, adding to the combination of factors causing impotence. free pennis enlargement exercise vimax penis enlargement program cheapest penis enhancement pills forum magna rx penis enhancement cream homemade penis enlargement penis elargement pills review free pennis enlargement video free exercise tip for penis elargement

If, like the majority of men in later life, you begin to experience problems with urinating then there is a good chance that you are suffering from a swollen or enlarged prostate. This condition, which is also known as BPH (benign prostatic hyperplasia or benign prostatic hypertrophy), will affect about half of the male population by the age of 60 and rise to about ninety percent of all men by the time they reach 80 years of age. Many men suffering from BPH will experience little if any enlarged prostate symptoms, but others will develop a range of symptoms associated with urinating including the need to strain in order to urinate, a weak or slow flow which starts and stops, a feeling that they have not emptied their bladder following urination, the need to urinate frequently and often with urgency and frequent awakening during the night to urinate. In the early stages of BPH these symptoms are caused by the enlarging prostate pressing on the urethra and restricting the flow of urine from the bladder. At this point the bladder is able to counter this to a certain extend by simply contracting more strongly to force urine through the constricted urethra. As time goes by however, and the enlargement of the prostrate continues, a point will be reached at which the bladder cannot force all of its contents through the urethra and the bladder can no longer empty completely. The restriction of the urethra and the inability to regularly flush out the bladder can also give rise to repeated urinary tract infections leading to a burning sensation or pain when urinating. Stones may also form in the bladder and this can lead to a complete blockage of the urethra and an inability to urinate at all. This is known as acute urinary retention and should be treated as a medical emergency. As a general rule the presence of enlarged prostate symptoms does not in itself mean that treatment is required and many men will simply live with these symptoms as long as they are not bothered by them too much. This said, enlarged prostate symptoms can also indicate the presence of other problems, or indeed mask other problems, and it is always advisable to consult your doctor and get an accurate diagnosis before deciding to let things be.