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Viagra (Sildenafil citrate), which millions of men take for erectile dysfunction (ED), reduces the effects of hormonal stress on the heart by half, according to a study published online in the journal Circulation. Viagra causes genital blood vessels to expand, which helps in maintaining an erection. Recent research also has pointed to its potential usefulness in treating pulmonary hypertension. Prior to the latest findings by a team of Johns Hopkins researchers, it was thought to have little effect on the heart. Viagra, or sildenafil, blunts the strengthened heart beat caused by chemically induced stress, according to study senior author and cardiologist David Kass, MD, a professor at the Johns Hopkins University School of Medicine and its Heart Institute. It thereby lessens both the excess amount of blood and the force used to pump it to the body. "Sildenafil effectively puts a 'brake' on chemical stimulation of the heart," says Kass. Prevents and Reverses Effects of High BP These findings are believed to be the first confirmation in humans that Viagra has a direct effect on the heart. In earlier research, Kass and his team observed a similar effect in mice; Sildenafil blocked the short-term effects of hormonal stress in the heart. Related studies by the group show that sildenafil also prevents and reverses the long-term effects of chronic high blood pressure on the heart. Sildenafil reversed the negative effects on heart muscle weakened by heart failure and enlargement -- a condition called hypertrophy -- in mouse experiments Kass and his team carried out earlier this year. They reported their results in the journal Nature Medicine. "But we had no firm evidence as to whether or how this therapy might work in the human heart," says Kass. "Our latest research provides firm evidence this drug does indeed have an important impact on the heart." Increased Heartbeat Was Slowed Thirty-five healthy men and women, with an average age of 30 and no previous signs of coronary artery disease, participated in the six-month Johns Hopkins study. Within a three-hour timeframe, each participant received two separate injections of dobutamine (5 micrograms per kilogram for five minutes), a synthetic, adrenaline-like chemical that increases heart rate and pumping strength. Between injections, study participants were assigned randomly to a group that was treated with sildenafil (100 milligrams taken orally) or to a group given a sugar pill placebo. All participants then were given the second dobutamine injection to see what effects sildenafil or placebo had on the heart. Measurements of heart function were made before and after each injection. These included blood pressure readings, electrocardiograms and echocardiograms. Blood samples confirmed relatively equal levels of sildenafil and other enzymes. Each dobutamine injection stimulated heart function, increasing heart rate and the force of each heartbeat used to pump blood throughout the body, results showed. "This stimulation is similar to the way the nervous system normally increases heart function when triggered by emotional or exercise stress, or in diseases such as heart failure," notes Kass. After the first injection of dobutamine, the force of heart contraction increased by 150 percent in both groups. In the placebo group, this increase repeated itself after the second injection. However, in the group treated with sildenafil, the increased heartbeat was slowed by 50 percent, resulting in a smaller increase in blood flow and blood pressure generated by the heart in response to chemical stimulation. Between injections, heart function was not altered in the sildenafil group, demonstrating the absence of adverse side effects on the resting human heart. Stops PDE5A Action "Knowing more about the effects of sildenafil on heart function will allow for safer evaluation of its use as a treatment for heart problems," says Kass. "Our results set the stage for further studies of sildenafil's immediate and long-term effects on the heart and its ability to modify other neurohormonal and stress stimuli, including adrenaline and hypertension," he adds. While the precise biological actions of sildenafil in the heart are not fully understood, the drug is known to work by stopping the action of an enzyme, called phosphodiesterase 5 (PDE5A), Kass explains. This enzyme is involved in the breakdown of a key molecule, cyclic GMP, which helps control stresses and limit overgrowth in the heart. PDE5A is also the biological pathway that sildenafil blocks in the penis to prevent the relaxation of blood vessels and thus maintain erections. Copyright 2005 Daily News Central penis enhancement pic penile enlargement review free exercise tip for penis enlargement vimax manual penis enlargement penis enhancement pills pennis enlargement pic penis enargement forum free penis elargement pills

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The most exciting event in Slovenia last week was when a group of young army recruits spat on the national flag and sang the anthem of the now defunct former Yugoslavia. They were sent to a military psychiatrist for observation. Indeed, economically speaking, a preference for any other part of the late Federation over Slovenia would indicate mental deformity. Slovenia is by far the most prosperous and pacific of the lot. Income per capita increased by 7% between 1995-2000 and reached 75% of the EU's average. Yugoslavia and Macedonia would require half a century to reach this level at current growth rates. Slovenia's public debt is negligible (c. 26% of GDP), its unemployment rate is almost American (less than 7%), its budget deficit a mere 1.4% of GDP. Slovenia's gross national savings is almost a quarter of its GDP - as is its gross domestic investment (28%). It is a respected member of both the World Bank and the IMF. The former has disbursed c. $250 million for purposes such as structural reforms and environmental cleanups. The latter praises its monetary targeting, the managed float of its tolar, and the lack of major (budget and current account) imbalances. This, despite erratic monetary management by the Bank of Slovenia, which, together with the introduction of VAT, the oil price shock, and a totally CPI-indexed financial environment, led to escalating inflation (c. 9% annually, up from 6%). Thus, should Slovenian officials fail in their efforts to secure agricultural and regional development concessions from their counterparts in Brussels, Slovenia runs the risk of becoming a net creditor of the EU. Slovenia, contrary to most other current members, is openly unhappy with the "Big Bang" enlargement of the Union. It has successfully concluded 22 out 29 chapters to be agreed with the EU prior to accession and it is afraid of being held back by an unrealistic, politically motivated, process of enlargement which will stress the EU's deficient institutions to their breaking point. Slovenia is small. It is the size of pre-1967 Israel or New Jersey. With less than 2 million citizens (88% of which are ethnic Slovene), its population grows by a paltry 0.14% p.a. Still, had it not constituted the northern boundary of a war prone and unstable region, Slovenia might have attracted more FDI (it has one of the lowest rates among the candidate countries), bordering as it does and integrated as it is with the (relatively) large and disinflated economies of Italy, Hungary, and Austria. Many Slovenes actually live in Jorg Haider's part of Austria (Carinthia). Italians owned property (confiscated by the communists) in Slovenia before the Second World War (the source of a simmering grudge in Italy). Italians, Austrians, and Germans invest in Slovenian banks, insurance companies, and industry. Together with Poland, Hungary, and the Czech Republic (among others), it is a member of the now reawakened CEFTA (Central European Free Trade Agreement). Only 4% of Slovenia's GDP derives from agriculture (vs. 61% from services). Still, Slovenia, to its great ire, is often associated with the Balkan. But the bad neighborhood is not the only obstacle. Slovenia's privatization was as crony-infested as elsewhere in the Eastern Bloc and its legislation still incorporates investment-deterring anachronisms (restricted land and media ownership, an over-regulated labour market, lack of corporate governance). Capital account liberalization was implemented only recently. Close to half of the economy (including a chunk of the favoritism-ridden and inefficient banking system) is in the hands of the state. The private sector, though, is thriving. Growth rates (4% this year) are double the European average and GDP per capita is almost equal to Greece's or Portugal's. Slovenia's international trade amounts to 60% of its GDP. Two thirds of it is with the EU (half of this with Germany and Austria, the former colonial mater). Its trade with Russia, the USA (3% of the total each), and even with other republics of the disintegrated Yugoslavia is marginal. It still purchases raw materials from Macedonia and Yugoslavia - and sells back to them the finished products (as it used to do in former Yugoslavia). But this does not amount to much. The decoupling is intentional - Slovenia considers itself an integral part of Western Europe. All it inherited from Communism, it feels, was polluted rivers and coastal water, acid rain, and depleted forests. Still, such exposure to the EU makes Slovenia susceptible to the Union's business cycles. Shortsightedly perhaps, it does not have a trade representation or an economic attaché in the USA. Of all its erstwhile confederates, Slovenia maintains tenuous political contacts only with Croatia. It just resolved a long standing dispute with Croatia regarding the Krsko nuclear power plant. Both countries agreed to continue discussions regarding the final demarcation of the hotly disputed (in Slovenia) border between the two countries as a prelude to the introduction of the Schengen agreement. Overtures are made to post-Milosevic Yugoslavia. Slovene legislation is eagerly copied by Macedonia. Gradually, albeit reluctantly, Slovenia comes to be regarded as a role model by its southern neighbors who strive to emulate its success. pnis enlargement before and after vimax natural penis enlargement technique best enlargment exercise penis cheapest penis enlarement pills manual penile enlargment truth about penis elargement safe penis enlargment natural penile enlargment penis enhancement product

Sex is an important part of a personal relationship. Don’t jeopardize your relationship due a mere dysfunction which can be treated effectively. Levitra is a magic potion that can relieve you of the erectile dysfunction (ED) with ease. Erectile dysfunction or dysfunction erectile impotence basically implies the failure to achieve or maintain erection until the completion of a sexual intercourse. Wondering how do you find out if you are coping with erectile dysfunction or not? Symptoms of erectile dysfunction or dysfunction erectile impotence include failure to achieve erection, inability to sustain erection, inability to enter into your cohort i.e. loss of hardness with penetration. Erectile dysfunction or dysfunction erectile can be a consequence of either physiological or psychological factors, or a combination of both. It can also surface due to side-effect of any medication that you might be engaged in, such as for alcohol consumption, smoking amongst others. Levitra drug is co-developed and co-promoted by Bayer and Glaxo Smith Kline. It is a FDA approved drug under Pregnancy category B. Yet, it is not recommended for consumption by women. Levitra drug works on the principle, which entails relaxing of the penis muscles thus enhancing blood flow into the penis to achieve a firm erection. Before embarking upon Levitra treatment prior consultation with your doctor is recommended. It is advisable to avoid consumption of Levitra if you are already engaged in medication constituting nitrates. In addition to Levitra, Cialis and Viagra are amongst other drugs that are available in the market to treat dysfunction erectile impotence. But Levitra has emerged as one of the most popular erectile dysfunction drug due to its promising positive results. Not only this, it can be obtained at a reasonable price and reflects lesser side-effects as compared to other erectile dysfunction drugs. It’s a misnomer that use of Levitra can guard you against sexually transmitted diseases. In order to protect yourself against sexually transmitted diseases such as HIV, you need to take proper precautions. For further information, kindly consult your doctor. End your quest for a solution to revitalize the passion within you. Levitra can help you to explore the bliss of sex life. homemade penis enlarement com elargement penis penis pump penis enlagement program best penis enlarement pills penis elargement pills product safe pnis enlargement enargement manhattan penis surgeon penis enlargement device penis enhancement product

Do women with stronger pelvic floor muscles experience better sex? Do they feel more pleasure during sexual activity and have more orgasms? The evidence suggests they do! The pelvic floor is a large hammock of muscles stretching from side to side across the floor of the pelvis in both women and men. It is attached to the pubic bone in front, and to the tail end of the spine behind. The openings from the bladder, the bowels and, for women, the vagina, all pass through the pelvic floor. The correct anatomical name for these muscles are the pubococcygeus muscles, but nowadays they are more commonly called the pc muscle or muscles, or even more commonly, the pelvic floor muscles. It is more actually more accurate to talk of these muscles in the plural, as there are a number of muscle groups that together make up this pelvic floor sling. Many women are aware that they should exercise these pelvic floor muscles but very few do it regularly and successfully. Most women who have had children will have been advised on the importance of pelvic floor exercise to restore muscle tone after childbirth, and muscle strengthening was identified as an appropriate treatment for stress urinary incontinence back in the 1950s. It was during the development of an exercise program for urinary incontinence that an interesting side effect was observed by Dr Arnold Kegel, the originator of these exercises. He claimed that women doing his exercises were finding it easier to reach more frequent and more intense orgasms. To understand why, consider what happens in your body when you experience an orgasm: Your heart pumps faster and your breathing gets heavier to fuel those tensing muscles. Hormones are pumped round your brain and body, telling you this is pleasurable. Blood is pumped to your genitals to create the tension that will ultimately trigger a pudendal reflex (muscular spasm of the genitals). The pudendal reflex will result in your pelvic-floor muscles contracting between five and 15 times at 0.8-second intervals. This is an orgasm as we know it. So when you consider that the essential experience of orgasm is focused on the pelvic floor muscles, it isn’t surprising that exercising and strengthening those muscles might make for more and better orgasms. The association between a strong pelvic floor and improved sexual response and pleasure led sex therapists to recommend pelvic floor exercises (or kegel exercises as they are known in the US) to clients, and earned the pelvic floor yet another name: “the love muscle”. So why are pelvic floor exercises helpful in increasing sexual pleasure? The pelvic floor muscles are directly responsible for the amount of sensation you feel during intercourse, and for the amount of grip felt by your partner. So although an exercise regime for the pelvic floor muscle has the same physiological benefits as exercising any other muscle, the spin-offs are much better. Exercise improves muscle tone which means that the muscle is tighter, so is stretched more by an erect penis. Strong, firm muscles have more nerve endings, and more nerve endings mean more sensations for you during sex. Exercise improves circulation, and this is particular important for the smaller muscles of the pelvic floor, which are responsible for engorging the clitoris when you are aroused. Rhythmic contractions of the pelvic floor contribute to arousal and to many women's ability to achieve orgasm. Many women report they are able to reach orgasm more easily, and that their orgasms are more powerful, after a pelvic floor exercise program. So why wait to start exercising your pelvic floor? Most experts agree that it takes approximately 12 weeks of exercising to make a real difference, so start now, and within three months, a better sex life could be yours! For information on how to exercise easily and effectively, visit www.pelvicfloorexercise.com.au. truth about pnis enlargement pills prosolution penile enlargment pills com enargement penis penis pump penis enlagement stretcher penis enargement system truth about penis enhancement pills vigrx pic herbal pennis enlargement penis enhancement product

Although it is true that almost every man is concerned about penis size, there are men who have never measured their Penis and aren't too concerned about its length. Looking at the history, there are poets, philosophers, writers and artists who have tried to determine what the average size is for manhood and what is considered above average. In erotic literature it is believed that a bigger penis is the symbol of manhood , sexual power and vigor. The question "Does size really matter?" is a common question, for both men and women. Men usually are obsessed, more or less about their penis size, while women are obsessed about their breast size. In fact, all of men think of how to find a way to make their member larger. These days, having bigger penis or larger breast is not difficult because the penis enhancement industry has undergone a great development. From penis enlargement pills, patches to creams, penis enlargement exercises and a lot of other natural products, like traction devices, and even surgery, there are various option available. The media and the stories with men with very large penises, has contributed to the already bizarre subject of penis size. Most specialists agree that the average penis size in erection is between 5.5 and 6.4 inches in length and about 4.7 and 5.2 inches in girth. Another fact that needs to be mentioned is that penis size does not depend of height or hand, feet, and nose, because there is no bone in the penis. But, penis size has some effect regarding the self confidence and self esteem which affect the sexual life in general. Though the length of the penis may have not much to do with sexual pleasure, the girth may have a big importance. It has something to do with stimulating the G-spot which is located about two inches inside the upper wall of the vagina as some therapists explain. In conclusion , this is still a matter of preference. While most women prefer a big penis because a bigger penis offers her intense pleasure and more pleasurable orgasms, at the questions "what do you prefer over penis length and penis girth a woman answered us that she likes her partner to have “meatier” penis, meaning fuller penis, because in her case the nerves in her vaginal walls, located near the entrance of the vagina and the anus, are better stimulated during intercourse. For this woman, girth has more significance instead of a meatier penis, because it can stretch out the vaginal or anal walls that stimulate the nerves. A penis with increased girth can create friction and sensation that most women crave for during intercourse. Most women say that even though the penis is the most important instrument in love making, it is also important to have a combination of skills, passion and romance that heightens the sensation. Saying that a man with a small penis is not good is a hasty generalization. Even if size matters, women are in general concerned about the man’s entire package, rather than just the one between their thighs. Women also seek passion, intimacy and emotional connection. See how you will impress her by giving her flowers, sensual massage or a bath with rose petals.