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Viagra (Sildenafil citrate), which millions of men take for erectile dysfunction (ED), reduces the effects of hormonal stress on the heart by half, according to a study published online in the journal Circulation. Viagra causes genital blood vessels to expand, which helps in maintaining an erection. Recent research also has pointed to its potential usefulness in treating pulmonary hypertension. Prior to the latest findings by a team of Johns Hopkins researchers, it was thought to have little effect on the heart. Viagra, or sildenafil, blunts the strengthened heart beat caused by chemically induced stress, according to study senior author and cardiologist David Kass, MD, a professor at the Johns Hopkins University School of Medicine and its Heart Institute. It thereby lessens both the excess amount of blood and the force used to pump it to the body. "Sildenafil effectively puts a 'brake' on chemical stimulation of the heart," says Kass. Prevents and Reverses Effects of High BP These findings are believed to be the first confirmation in humans that Viagra has a direct effect on the heart. In earlier research, Kass and his team observed a similar effect in mice; Sildenafil blocked the short-term effects of hormonal stress in the heart. Related studies by the group show that sildenafil also prevents and reverses the long-term effects of chronic high blood pressure on the heart. Sildenafil reversed the negative effects on heart muscle weakened by heart failure and enlargement -- a condition called hypertrophy -- in mouse experiments Kass and his team carried out earlier this year. They reported their results in the journal Nature Medicine. "But we had no firm evidence as to whether or how this therapy might work in the human heart," says Kass. "Our latest research provides firm evidence this drug does indeed have an important impact on the heart." Increased Heartbeat Was Slowed Thirty-five healthy men and women, with an average age of 30 and no previous signs of coronary artery disease, participated in the six-month Johns Hopkins study. Within a three-hour timeframe, each participant received two separate injections of dobutamine (5 micrograms per kilogram for five minutes), a synthetic, adrenaline-like chemical that increases heart rate and pumping strength. Between injections, study participants were assigned randomly to a group that was treated with sildenafil (100 milligrams taken orally) or to a group given a sugar pill placebo. All participants then were given the second dobutamine injection to see what effects sildenafil or placebo had on the heart. Measurements of heart function were made before and after each injection. These included blood pressure readings, electrocardiograms and echocardiograms. Blood samples confirmed relatively equal levels of sildenafil and other enzymes. Each dobutamine injection stimulated heart function, increasing heart rate and the force of each heartbeat used to pump blood throughout the body, results showed. "This stimulation is similar to the way the nervous system normally increases heart function when triggered by emotional or exercise stress, or in diseases such as heart failure," notes Kass. After the first injection of dobutamine, the force of heart contraction increased by 150 percent in both groups. In the placebo group, this increase repeated itself after the second injection. However, in the group treated with sildenafil, the increased heartbeat was slowed by 50 percent, resulting in a smaller increase in blood flow and blood pressure generated by the heart in response to chemical stimulation. Between injections, heart function was not altered in the sildenafil group, demonstrating the absence of adverse side effects on the resting human heart. Stops PDE5A Action "Knowing more about the effects of sildenafil on heart function will allow for safer evaluation of its use as a treatment for heart problems," says Kass. "Our results set the stage for further studies of sildenafil's immediate and long-term effects on the heart and its ability to modify other neurohormonal and stress stimuli, including adrenaline and hypertension," he adds. While the precise biological actions of sildenafil in the heart are not fully understood, the drug is known to work by stopping the action of an enzyme, called phosphodiesterase 5 (PDE5A), Kass explains. This enzyme is involved in the breakdown of a key molecule, cyclic GMP, which helps control stresses and limit overgrowth in the heart. PDE5A is also the biological pathway that sildenafil blocks in the penis to prevent the relaxation of blood vessels and thus maintain erections. Copyright 2005 Daily News Central penis elargement information homemade penis enlagement natural penis enlarement penile enlargment testimonials cheap penis enhancement vimax male virility sexual enhancement plastic surgery penis enlagement natural penis enlagement technique

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Erectile dysfunction is a common problem for more than half of men with diabetes. A recent study from the Brady Urological Institute at Johns Hopkins suggests that an over-supply of a simple blood sugar could be a major cause of erectile dysfunction in diabetic men. Describing the mechanism of erection, the research team has determined that high glucose in diabetes mellitus is an interrupting factor of this process. Erection begins when a sexual stimulus activates the enzyme neuronal nitric oxide synthase (nNOS) that causes short-term release of nitric oxide (NO) at the nerve endings in the penis. This initial release of NO causes short-term and rapid increases in penile blood flow and short-term relaxation of the penile smooth muscle, initiating an erection. The resulting expansion of penile blood vessels and smooth-muscle relaxation allows more blood to flow into the penis. This increased blood flow (shear stress) activates the eNOS in penile blood vessels causing sustained NO release, continued relaxation and full erection. O-GlcNAc, a blood sugar present in hyperglycemic (high blood sugar) circumstances, hinders this normal chain of events by inhibiting the activation of eNOS, and consequently reducing the release of NO and preventing the smooth muscle in the penis from relaxing. Without this relaxation, there is no shear stress to stoke the production of more NO and therefore, no normal, sustained erection. This is not the same type of erectile dysfunction seen in non-diabetics, and it is less effectively treated with conventional drugs like Viagra. The mechanism described above stresses the critical importance of vascular function in the erectile response. It may suggest new ways of treating erectile dysfunction by targeting specifically this mechanism in penile erection. herbal penis enlargement pills real penis enhancement natural penis enhancement and lengthening do penis enlarement pills really work truth about pnis enlargement pills penis enhancement supplement vimax does penis enlargement work penile enlargment patch penis enlarement

Sex is in the brain and the brain sends signal of fulfillment and pleasure to the body after an orgasmic sexual activity. But there are millions of men who fail in having the immense pleasure of love making due to erectile dysfunction. Erectile dysfunction (ED) commonly called impotence is a physical condition in men’s health when he is unable to achieve or maintain an erection sufficient for fulfilling his sexual needs or the needs of his partner, consistently over a period of time. The cure for such a sexual health condition was unthinkable. Couples in love whose female partners stuck by them in their difficult period had to rely on fantasy sex and enact their own fantasy sexual stories. But the men always had a sense of guilt for not being able to deliver to the needs of his partner’s sexual fantasies. In 1998, Pfizer Pharmaceuticals manufactured the first drug Viagra, for the treatment of erectile dysfunction. Viagra (sildenafil) is an oral prescription drug which is to be used only after consulting a physician. Its active ingredient Sildenafil citrate enables many men with ED to respond to sexual stimulation. When a man is sexually aroused, the arteries in the penis relax and widen, allowing more blood to flow into the penis, resulting in an erection. Thus men using Viagra were able to revitalize their sex life like never before. But, like all good things, Viagra also has its share of liabilities. Viagra intake without proper clinical examination (to the body’s resistance capacity for active sex) and probabilities for drug interactions and side-effects might be dangerous. Men should not be carried away by their sexual fantasies and have Viagra just for the lust of it. If you suspect yourself to be suffering from impotence, do not hesitate to approach your doctor or you can collect sufficient Viagra information over the Net. With the advent of Viagra, erectile dysfunction has become a thing of the past. Earlier, men suffering from ED always had the inferiority complex of not been able to live-up to his partner’s female sexual fantasies. This often created sexual disharmony in a relationship. He sometimes failed to understand that a woman’s sexual fantasies need not always be her wishes. Sexual fantasies can be a healthy aid if used with comfort, concern and mutual understanding. Viagra has over the years revolutionized the concept of failure. Men using Viagra for treating erectile dysfunction has become more comfortable and confident of his sexual prowess. It will not be exaggerating to say that - Viagra has transformed an impotent man into a Viagra man. vigrx pill vimax penis enlargement operation vimax penis enlargement technique vimax guide to penis enlargement magna rx pills cheap penis enlagement penile enlargment secret best penis enlargement pill penis enlarement

Yes, by all means, but it is technically called hypogonadism (low testosterone levels). Symptoms may vary, but most men will experience decreased libido (sexual desire) as well as erectile dysfunction, hot sweats, decrease in body hair, fatigue, or even depression. They also tend to lose muscle mass and gain weight due to increased subcutaneous fat. Erectile dysfunction is a common complaint of male patients past the age of 50, and although it is most commonly caused by such problems as vascular insufficiency (decreased blood flow) to the penis which usually responds well to such medications as Viagra, Cialis, or Levitra, your physician should check for hypogonadism as a possible cause and also screen for cardiovascular disease as well as diabetes. Certain prescription medications can also lead to problems with both libido and sexual dysfunction; most notably certain anti-depressants and hypertensive medications. Serum testosterone levels are at their highest between the ages of 20 to 30 and tend to progressively fall after age 40. If your testosterone levels come back low, your physician may wish to order a couple of other tests to determine the actual cause. There are other causes of low testosterone other than merely aging. If your testosterone level IS low and you are going to receive treatment, make sure that you are screened for prostate cancer. Your doctor should perform a digital rectal exam, order a PSA (prostate specific antigen) blood test, and your testicles should be examined for size, nodules and other abnormalities. Topical testosterone gel is usually the preferred method of administering the hormone. Topical 1% testosterone is available as Androgel or Testim. The starting dosage is 5 gm a day and applied to dry skin of the abdomen, upper arm or shoulders. The gel should not be placed on the genitals! The area of skin should be allowed to dry and a shirt be worn during contact with children or women as it IS possible to transfer the medicine to the skin of another individual. The serum testosterone level should be determined again about two weeks after initiating treatment. The administration of testosterone replacements have NOT been demonstrated to increase the incidence of prostate cancer, myocardial infarction, cardiovascular disease, or stroke. It can, however, elevate the PSA (prostate specific antigen) level. Treament has come a long way over the past few years with the advent of the topical applications. Testosterone used to be given by intramuscular injection which was both painful and had to be given rather frequently because the levels of the medication would not last long in the blood stream. The topical applications tend to maintain an even level of medication at all times without the peaks and valleys caused by the old injections. Testosterone replacement should improve libido, muscle mass, and well being. It can aggravate sleep apnea, cause mild acne, and gynecomastia (slight enlargement of the breasts), but NOT in everyone. It can enable a male to feel much more vibrant, improve his sexual desire, ability, and performance, and make life a lot more enjoyable overall. Copyright 2006 Ted Crawford penis enhancement tool vimax enlargement manhattan penis manual penile enlargement homemade penis enlargement penis enlagement information vigrx pills vigrx penis enlargement pills vig rx penis pill penis enlarement

Vaginal Wetness during Sex: YOU MAY BE WETTER THAN NECESSARY! Most of us assume that sex is best when wet, but are you feeling as much as you could be from intercourse? Just like a car engine, there is an upper and lower range that is required for maximum performance. Too much natural lubrication (wetness) during sex reduces pleasure for both partners. Females lose greater stimulation along the vaginal walls. Men lose out on the corresponding ‘tight’ sensation that they love. We all have an optimum level of friction that is required to enable heightened pleasure for both partners, thus leading to easier climax. This level of stimulation can most easily be obtained by experimenting with your wetness level. Sex could be much more satisfying than what you think it already is. A woman’s wetness level increases naturally as arousal increases. But for some ladies, even the slightest turn-on is enough to produce an extravagant amount of lubrication. If excess wetness is a problem for you, OR if you wish to simply experiment with different levels of wetness, seeking the most pleasurable ‘tight’ sensation for your man, what can you do? First, realize that there is more involved in sex than just the intercourse part of it. More women achieve orgasms by clitoral stimulation than by intercourse. However, intercourse is an intimate act & should be satisfying when possible. If it is not enjoyable, then a couple will more than likely become romantically distant. This is the beginning of marriage deterioration. Secondly, you should see your doctor to be sure there is no infection, abnormalities, or other problem causing your excess wetness, especially if it is something new. Don’t take chances! Medical Options: The most radical solution to excess wetness is surgery. This should be your last resort, & is rarely necessary. Other medical procedures include freezing or lasering the cervix to reduce secretions, electrical stimulation, & treatment with magnetic fields. These treatments can variously be painful, costly, & time consuming. There is no guarantee of success or that the problem will not return. Non-Medical Options: There are numerous options, but few realistic ones. Here are some common things couples try (including some “old wives tales”) & comments about their effectiveness. 1) Anything that dries up the mouth. In general, if it dries the mouth, then it will also affect the vagina somewhat. Examples would be decongestants, antihistamines, cold formulas, certain antidepressants, alcohol, cigarettes, & marijuana. While these may work to some degree, wetness & corresponding tightness levels are not controllable, not to mention that a dry mouth is not as tasty during kissing & is more conductive to bad breath due to lack of saliva. 2) Try an Alum Douche. We’ve heard of this, but don’t know any doctor recommending it. Alum acts to contract walls of vagina, but can be irritating & cause yeast infections. There’s no way to judge how long it will last nor a way to control the extent of tightening 3) Use a ribbed condom or penis sleeve. Excess wetness remains a problem with or without a condom. Penis sleeves help the man feel more, but tends to numb the woman’s vagina after a few minutes, making her uncomfortable. 4) Douche with plain water. This has some impact by reducing the amount of natural lubrication, but the effect tends to vanish as the woman’s arousal increases, resulting in secretion of even more lubrication. 5) Insert a sponge or cloth. One of the more embarrassing techniques as it must be done intermittently. Couples find this a big turn off. The technique though, is to wrap a thin sheet/towel around a couple of fingers. Insert the fingers to soak up vaginal wetness. Proceed with intercourse. Repeat as necessary. While this method does work, re-entry of vagina is difficult & painful because this method absorbs ALL the lubrication. Within a few minutes however, as arousal increases again, there will once again be too much wetness. With this method, there is no way of controlling the desired level of wetness & tightness. 6) Use of a fan blowing on the genital area. Not a practical solution, as it primarily results in making the couple cold, while having little impact on internal vaginal secretions. 7) Use of birth control pills. An old wives tale without any validity. 8) Repositioning her body. Certain positions, such as closing of the legs, act to tighten the vagina, but unless the man has a longer than average penis, he will find it far less satisfying due to shallower penetration. 9) Insert an ice cube into the vagina to cause muscle contraction. Another old wives tale, not to mention the obvious discomfort. 10) Vaginal Cones. Very similar in concept to kegal exercises. The idea here is to exercise the vaginal muscles by holding an object inside the vagina by flexing the interior muscles. Increasingly heavier weights can be placed inside. The theory is sound, but females have a difficult time staying on this type of program long enough to be of benefit, not to mention that like any muscle, if it is not continually worked, it will lose its strength. The other disadvantage is that to be of benefit during intercourse, the female must consciously flex her interior muscles, thus taking away from her ability to relax & enjoy the act of intercourse itself. 11) Creams. There are a couple of these on the internet now being marketed under many different names. If you already suffer from excess wetness, adding a cream to the existing problem is not going to help. Manufacturers say the creams have a tightening effect on the vagina within 15-30 minutes, but evidence shows that any NOTICEABLE tightening effects is minimal to none. Application of the cream to the interior walls of the vagina is difficult, embarrassing & must be properly timed to correspond with intercourse. Some of the creams contain benzocaine, alum or Vaseline, none of which are recommended for being inserted into the vagina. To check out more on these creams, look on the internet under ‘vaginal tightening.’ 12) AbsorbShun natural powder. Is an ‘all-natural’ powder that either the man or woman can apply to the man’s penis. It is simple & quick to use, & has a noticeable moisture absorbing effect within 1-2 minutes. The more powder used, the more absorption, thus allowing the couple to find (and control) their most preferred moisture & tightness level. For more information on this product, go to www.absorbshun.com Whatever option you choose, you should look for a solution that is satisfactory for both partners. Finding the right level of lubrication can lead to greater sexual pleasure, more frequent sex, & a closer relationship between partners.