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With an ex-Presidential candidate as its pitchman, more mentions on late-night talk shows than Joan Embry and the dubious honor of being the world’s top pharmaceutical treatment for impotence, few drugs in history have been more in the public eye more than Viagra – or gotten more attention for affecting the public's eyes. Along with its impact below the belt, Viagra (Sildenafil Citrate) is well-documented to cause retinal dysfunction lasting several hours after it is taken. Most commonly, it causes increased light sensitivity, blurring, and a bluish tint or haze to vision in many men who take the medication.
Since receiving FDA approval in March 1998, Viagra has been prescribed more than 22 million times in the U.S. alone and is available in 90 other countries, according to manufacturer Pfizer. Here’s what you need know about Viagra and your vision:
Who is most likely to get ocular side effects?
Viagra is available in three prescribed doses – 25, 50 and 100 mg pills. Side effects are usually dose-related, meaning the greater the dosage, the greater the risk. According to reports by Pfizer and subsequent studies, ocular side effects occur in:
About 3 percent of men taking doses of 25-50 mg
About 11 percent taking 100 mg doses
About 50 percent of men taking 200 mg
Nearly all men taking 600 to 800 mg.
Why does Viagra cause vision changes? Viagra is effective on erectile dysfunction because it inhibits phosphodiesterase 5 (PDE-5), an enzyme that enhances the effects of nitric oxide, which is released during sexual stimulation to relax the smooth muscle of the penis and facilitate blood inflow. However, the drug also has a milder inhibiting effect on PDE-6, an enzyme actively present in retinal photoreceptors. This causes an increase in the concentration of cyclicGMP, resulting in a depolarization of the rod cell – and increased light sensitivity and the infamous "blue vision."
When do side effects occur? The side effects are short-lived and generally peak within 1-2 hours after the drug is taken. What is the long-term vision damage? Hard to say, since the drug has been on the market for only a few years. So far, no long-term retinal damage has been reported, but then again, long-term electroretinograms (ERG) have not been done, says Michael F. Marmor, MD, a Stanford retinal specialist who has published studies on the ophthalmic effects of Viagra. He believes the drug could conceivably result in lasting damage to photoreceptors, so he recommends that you avoid it if you have macular degeneration, diabetic retinopathy, retinitis pigmentosa or other retinal disease. (Meanwhile, Viagra's own label issues warnings to patients with existing AMD or retinitis pigmentosa because they were not studied in past clinical trials.)
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For years I have purchased soy milk, stocked it on my shelf, told myself I should open it and include it into my diet. After opening it though, it just sits in the refrigerator for a month or two. Then, of course, it’s too old to drink, so I throw it down the sink and the cycle repeats itself a couple months later. Now I believe that my body was telling me that it didn’t want the soy milk as I’ve been reading up on the soy controversy lately. Here is a summary of that information. . .
Isoflavones—the estrogen-like hormones that all work to help you stay young and healthy may not be the magical food that you have been led to believe. Soy is just one example of the many fad foods/ supplements/ cures that I find myself exposed to in trying to decipher the long-term health benefits before sharing them with my clients.
Soy has been marketed as a health food when, at one time, it was only a toxic by-product of the vegetable oil industry. Hmm. . . .that doesn’t sound right, does it? Don’t we eat soy in lots of things now?
Advances in technology make it possible to produce Soy Protein Isolate (SPI) from what was once considered a waste product—defatted, high-protein soy chips—transforming something that looks and smells terrible into products that can be consumed by human beings. Flavorings, preservatives, sweeteners, emulsifiers and synthetic nutrients have turned SPI, the food processors' nightmare into a very lucrative business.
All soybean producers pay a mandatory assessment of one-half to one per cent of the net market price of soybeans. The total—something like $80 million annually—supports United Soybean's program (http://www.ams.usda.gov/lsg/mpb/rp-soy.htm) to "strengthen the position of soybeans in the marketplace and maintain and expand domestic and foreign markets for soybeans and soybean products."
Soy milk, made from raw soy, has posted the biggest gains, soaring from $2 million in 1980 to $300 million in the United States last year. Recent advances in processing have transformed the gray, thin, bitter, beany-tasting beverage into a product that Western consumers will accept.
The first soy foods were fermented products like tempeh, natto, miso and soy sauce. At a later date, possibly in the 2nd century BC, Chinese scientists discovered that a purée of cooked soybeans could be precipitated with calcium sulfate or magnesium sulfate (Plaster of Paris or Epsom salts) to make a smooth, pale curd they called tofu or bean curd.
The Chinese never ate unfermented soybeans as they did other legumes such as lentils, because the soybean contains large quantities of natural toxins or "antinutrients." These antinutrients are not completely deactivated during ordinary cooking. They can produce serious gastric distress, reduced protein digestion and chronic deficiencies in amino acid uptake. In test animals, diets high in these antinutrients called trypsin inhibitors cause enlargement and pathological conditions of the pancreas, including cancer.
Other harmful substances in soy products include haemagglutinin, goitrogens, phytic acid, nitrates, and phytoestrogens (in large amounts.) What are these things? Well. . .
Haemagglutinin is a clot-promoting substance that causes red blood cells to clump together.
Trypsin inhibitors and haemagglutinin are growth inhibitors that are deactivated during the process of fermentation. In precipitated products (like tofu,) enzyme inhibitors concentrate in the soaking liquid rather than in the curd. Thus, in tofu and bean curd, growth depressants are reduced in quantity but not completely eliminated.
Soy also contains goitrogens - substances that depress thyroid function. This is a major concern of mine as I see our population having more and more thyroid issues with each passing year.
Soybeans are also high in phytic acid, present in the bran or hulls of all seeds. Phytic acid can block the uptake of essential minerals—calcium, magnesium, copper, iron and especially zinc—in the intestinal tract. Scientists are in general agreement that grain and legume-based diets high in phytates contribute to widespread mineral deficiencies in third world countries.
The Japanese have traditionally eaten small amounts of tofu or miso as part of a mineral-rich fish broth, followed by a serving of meat or fish. This is not how vegetarians and vegans consume soy. The results of calcium, magnesium and iron deficiency are well known; those of zinc are less so. These are the exact mineral deficiencies I have been seeing in my practice.
Many people in my practice now come in with that tell-tale tan chin, indicative of iron deficiency. They are low in energy and worried about osteoporosis, but they look like thyroid cases. Their thumbs point toward their hips as they stand and walk instead of pointing forward, and they carry more weight evenly dispersed on their body. Most of my clients are also low in zinc.
Zinc is needed for optimal development and functioning of the brain and nervous system, it is used in protein synthesis, collagen formation, in the blood-sugar control mechanism thus protecting against diabetes, and is needed for a healthy reproductive system. Zinc is a key component in numerous vital enzymes and plays a role in healthy immune system function These uses are among hundreds of other ways zinc is used by the body.
Soy processors have worked hard to get these antinutrients out of the finished product, particularly soy protein isolate (SPI), the key ingredient in most soy foods that imitate meat and dairy products, including baby formulas and some brands of soy milk. (For more information on that, read my other article on soy, The Hazards of Feeding Soy to Children.
Nitrites, which are potent carcinogens, are formed during the spray-drying process of making Soy Protein Isolate (SPI). Test animals fed SPI develop enlarged organs, particularly the pancreas and thyroid gland, and increased deposition of fatty acids in the liver.
If this is so, then why are SPI and textured vegetable protein used extensively in school lunch programs, commercial baked goods, diet beverages and fast food products? (Yikes!) Soy is also heavily promoted in third world countries and forms the basis of many food giveaway programs.
Researchers studying soy-based foods in one school research project noted several alarming symptoms after children ate soy-based meals including: "occasional" vomiting, periods of moderate diarrhea, upper respiratory infections, rashes and fever.
Many ask then, why do the Japanese have less cancer than Americans? Do they? I’ve heard over the years that the Japanese, who allegedly eat 30 times as much soy as North Americans, have a lower incidence of cancers of the breast, uterus and prostate. BUT the Japanese, and Asians in general, have much higher rates of other types of cancer; particularly cancer of the esophagus, stomach, pancreas, thyroid and liver.
Just how much soy do Asians really eat? A Cornell study conducted by Colin T. Campbell in 1998 found that the average daily amount of soy protein consumed in Japan was about eight grams for men, and seven for women. This is only less than two teaspoons. Do Japanese really eat more soy than Americans? At this point, I don’t think so.
Except in times of famine, Asians consume soy products only in small amounts, as condiments—not as a replacement for animal foods—with one exception. Celibate monks living in monasteries and leading a vegetarian lifestyle find soy foods quite helpful—because they dampen libido.
So what are the side-effects of too much soy? (These are only in alphabetical order and not by the proportion of incidence.)
•Bloating
•Breast cancer (Soy isoflavones mimic estrogen)
•Calcium deficiencies (soy blocks calcium absorption)
•Cognitive decline (esp. in post menopausal women that have increased levels of estrogen in their blood)
•Constipation
•Depression
•Endocrine disruption
•Fatigue
•Goiter
Hair loss
•Hot flashes
•Hypothyroidism
•Infertility
•Irregular periods
•Lethargy
•Loss of muscle tone
•Painful periods
•Premature aging
•Thyroid cancer
•Thyroid disease
•Thyroid Stimulating Hormone increase
•Uterine cysts
•Vitamin D deficiencies
•Weight gain despite workouts and dieting
How much is too much soy? In 1991, Japanese researchers reported that consumption of as little as 30 grams or two tablespoons of soybeans per day for only one month resulted in a significant increase in thyroid-stimulating hormone, and 100 grams of soy protein, (promoted for its bone-building isoflavones and cholesterol-lowering effects) contains the estrogenic equivalent of the Pill. In vitro studies suggest that isoflavones inhibit synthesis of estradiol and other steroid hormones. I wonder if it’s really safe to take this kind of supplement if you have a family history of estrogen-influenced breast cancer. I don’t think I’d chance it. We get enough xenoestrogens in our environment as it is.
Some Helpful References: http://www.biotech-info.net/soya.html (Soy in the news) http://www.haelan.co.uk/Wholefood-Soya.shtml (Soy as a health food)
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Sex is a natural instinct, which every creature wishes to enjoy utmost. Getting one’s sex life deteriorated causes deep worries to men of all ages, as they cannot enjoy their sex life properly. Impotency or Erectile Dysfunction (ED) is one of the most found sex related disease which male tend to attain.
Levitra medication was approved by FDA in 2003 as a prescribed oral pill for cure of impotence or Erectile Dysfunction (ED). The problem ED causes with male is that they are unable to maintain their penis erection for complete duration of sexual activity. Levitra is an innovative drug to help such people suffering from ED.
Medication of Levitra works by blocking an enzyme known as PDE-5. This enzyme is responsible for affects the blood flow to the penis. Levitra is PDE-5 inhibitors which work by blocking this enzyme. Blockage of this enzyme prolongs the erectile process and enables one to retain his penis erection.
For most men, the recommended starting dose of Levitra medication is 10 mg. This pill has to be taken about 1 hour before sexual activity. It starts working within 16 minutes of its intake and may last for up to 24 hours. But, it must be remembered that to get erection, it is necessary to have some form of sexual stimulation.
One has to be aware of all side effects of Levitra medication before using it. Some side effects are headache, flushing, dizziness, runny nose, joint pain, severe chest pain, high or low blood pressure, etc. If one is using drugs containing Nitrate and Alpha- blockers, Levitra should be refrained from taking.
Levitra medication is a prescription based medicine to cure impotence or Erectile Dysfunction. Before taking this medicine one must discuss all his health conditions with doctor. Using this drug with appropriate care, one can achieve desired erection, and can make his sex life relishing.
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I don’t know how people raise daughters because I have 2 sons. In my in-sanest moments, I have thought about having a daughter and have entertained thoughts about rushing into Toys’Rus straight to the Barbie doll section. My preoccupation with daughters is short-lived. Then I become sane all over again – I must be out of my mind thinking about having another child! No way, it’s totally, absolutely, positively, undoubtedly out of the question. I do love babies. Oh, how I do love them. Pinching cheeks is not one of my favorite things to do an infant but I sure do love the feel of their feathery skin that is layered with fine, fine hair. I can’t resist touching their bums like a lunatic.
I am quite sure daughters are fun. Sometimes I watch other mothers fuss with their daughter’s hair and I look at Joshua and Jared and think to myself, “You think daddy will still love them if I leave their hair long so that I can tie them in braids and put ribbons on them?” My sons are pretty pretty, if I do say so myself but I don’t think they’d like me to dress them up as girls.
I tried.
Dressing my boys as girls Joshua already knows the difference between girls and boys – after the countless number of times we’ve broached the topic, how could he NOT know??? The times when we laughed till we were rolling around in unabashed nakedness in the bathroom because he thought I dropped my penis? Classic case of sex education gone folly. Jared, in the meantime, kept lifting up the skirt to see where the pant is one time I dressed him up as a Cinderella. I guess, it’s not going to work.
My confusion and problem on dealing with little girls started when I realized that I don’t know how to buy pretty dresses and fancy head gears for girls. Mind you, although I DO have a critical eye out for fashion faults, I am not a very good dresser. I prefer the slip-on-and-go-and-don’t-feel-like-I-am-wearing-anything-at-all types of clothes. If I had to insomuch as zip, button, snap-on, clasp or buckle anything, I’d feel like dressing was too much of an effort. Naturally, being the ‘casual dresser’ that I am (my family members refer to it as ‘sloppy’ but I object), I find myself in a mental maze whenever I have to buy gifts for girls. And in this month itself, there are two. One is for my 9-year-old cousin (being 32 this year, I have a pre-puberty cousin? Yes, I do. So, sue me) and another is for my niece, who’s turning 3 this month.
Birthday present problem For my cousin, I was thinking about buying soft toys because it’s hard to go wrong with soft toys. I mean, doesn’t everybody adore soft toys anymore? But no, I decided against it. I went into the clothes department to get her some fairy costumes, a princess crown or glass slippers, whatever! But it occurred to me that I didn’t know how to pick out female clothing at all. Then, I jogged myself into the stationery department, thinking of getting her a school bag. Boy, a school bag? How boring can I be? So, off I go again, into the books department this time. And I got her something that I don’t know whether she will like or not – but I am quite sure it’s hard to go wrong with books. Furthermore, I know I would have loved to get books as a present if I was still 9-years-old. Granted the fact that I was a major bookworm at that time.
It’s even worse for my 3-year-old niece – I went from one department to another, shopping mall to shopping mall for days on end. Up till today, I come home empty-handed, wide-eyed and clueless. What in the world do you buy for a 3-year-old girl who already has everything she can ever wish for?
“Bah!” to girls.
Tackling Another thing that bothers me is that I tend to be a little….erm….adventurous and wild with my kids. They’re boys, so, they naturally like to roughhouse a little and jump, hop, skip, run, hide, scare….tackle each other. And being a good mom, that’s precisely the kind of games that I play with them. I tackle them to the ground, wrestler-fashion, knocking my knuckles into their skull, digging my fingernails into their backs and sides, biting into the butts, pushing their heads into pillows…..
When my nieces come into the room and take one look at the kind of games that we’re playing with each other, they have 2 different reactions. One, they gape at us. Two, they want to join us but is afraid to. I remember playing the roughhousing game with one of my nieces, throwing her up in the air the way I throw Jared. She went stiff like a baseball bat in the air and when I caught her back into my arms, she looked like she was going to barf! Her face was green and her lips suddenly had cracks on them.
I gingerly placed her back on the floor and she sped out of the room.
As for having a daughter, forget about it. I’ll stick with my two monsters and continue with our snarling and growling activities until they decide that they want to play Barbie with their girlfriends. I will continue to enjoy my boys….until next year rolls around.
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About 13 million men in the USA suffer from the reduced sexual desire, depressed and varying moods, loss of energy, tiredness, erectile dysfunction and inability to achieve penetration during intercourse. These symptoms affect the persons over 45 years of age. The main reason behind this is the inability of the body to make testosterone in sufficient levels.
The symptoms are also known as hypogondadism or low T. Testosterone is an important ingredient in the blood and continued reduction of T levels gives rise to the complaints cited above
Now You Have a Treatment for Low T
The low T levels can now be treated with a gel known as androgel (or Testim). This is a brand name of the product with a generic name testosterone and comes in a gel form.
This gel can be applied on skin and this way it becomes a convenient way of administering the drug. Injections and skin patches are other ways of administering this drug. However, with gel becoming an option, easier ways of drug administration has come up.
The gel will help you in combating hypogonadism, you might have an increased sexual desire, energy to keep with your work, and the bone density will increase.
How To Use The Gel
After shower, you may apply the gel to your body. The gel comes in form of packets of 5 mg, 7.5 mg or 10 mg. Buy the sachets as prescribed by the doctor and take in the entire contents of packets on your palm and apply it to hands, shoulders and abdomen. You should not apply it to your genitals. This way, the drug might cause harm than doing any good. After application of the drug, wash your hands thoroughly with soap so as to remove traces of the drug.
What To Do After Applying Drug
After applying the drug, you should allow it to dry for at least 15 minutes before dressing up. This is necessary for the drug to be absorbed into your system and prevent its transfer to others through contact with body. Make sure that you have contact with water through bath, or swimming. If you miss a dose apply a dose as soon as practicable and if it is nearer to your regular dose, skip a dose and apply the next dose at the appointed time.
What Not To Do After Application Of Dose
Men using the gel should avoid contact of the areas where the drug was applied with other persons especially women. Pregnant women coming in contact with such areas should see the doctor immediately. The contact may harm the unborn child badly.
Possible Side Effects Of Drug
This drug, as many other drugs, can have unintended side effects. The side effects can be in form of reaction from site where the drug was applied, high blood pressure headache or breast enlargement. It is also possible that the sexual desire will decrease to some extent. The patient may also experience hot flashes, swelling of hands, and some times hair loss too.
The drug is to be used only after being prescribed by a competent medical practitioner
